Overview: I am interested in developing and applying advanced microscopy techniques to decipher functional and structural organisation of life at multiple scales. For this, I develop analytical and optical tools. You can find me on Twitter (@LaineBioImaging), in the optics lab tinkering with microscopes or on my computer developing image analyses.
Background and how I ended up coming to the LMCB? French but I have been living in the UK for long enough to have forgotten how real buttery pastries taste like. I did my PhD at Imperial College in biophotonics (throwing lasers and microscopes at cells and molecules !), then moved to Cambridge for PostDoc to develop super-resolution microscopy (throwing more lasers and more microscopes at cells and molecules !). I now joined Ricardo’s lab and I want to exploit my microscopy skills to study more complex biological systems with my microscopy skills (throwing some cells at my microscope!).
Reason(s) that made me get into science? The idea (and ideal) of discovery!
Where do I see myself in 5 years? Head of my own lab, working on fast 3D microscopy to understand viral replication at cellular and sub-cellular levels.
Any hobbies? Capoeira and cooking ! (a well-balanced system of input and output of calories).
Research themes with our lab
Publications with our group (see more on Google Scholar)
| Application of Super-Resolution and Advanced Quantitative Microscopy to the Spatio-Temporal Analysis of Influenza Virus Replication |
Emma Touizer, Christian Sieben, Ricardo Henriques, Mark Marsh, Romain F. Laine
Published in Preprints.org, January 2021 (see preprint)
| Single-molecule super-resolution imaging of T-cell plasma membrane CD4 redistribution upon HIV-1 binding |
Yue Yuan, Caron Jacobs, Isabel Llorente Garcia, Pedro M Pereira, Scott P.Lawrence, Romain F Laine, Mark Marsh, Ricardo Henriques
Published in bioRxiv, January 2021 (see preprint)
| An Introduction to Live-Cell Super-Resolution Imaging |
Siân Culley, Pedro M Pereira, Romain F Laine, Ricardo Henriques
Published in Imaging from Cells to Animals In Vivo, November 2020 (see publication)
| ZeroCostDL4Mic: an open platform to simplify access and use of Deep-Learning in Microscopy |
Lucas von Chamier, Johanna Jukkala, Christoph Spahn, Martina Lerche, Sara Hernández-pérez, Pieta Mattila, Eleni Karinou, Seamus Holden, Ahmet Can Solak, Alexander Krull, Tim-Oliver Buchholz, Florian Jug, Loïc Alain Royer, Mike Heilemann, Romain F. Laine, Guillaume Jacquemet, Ricardo Henriques
Published in bioRxiv, March 2020 (see preprint)
| Fluctuation-Based Super-Resolution Traction Force Microscopy |
Aki Stubb, Romain F Laine, Camilo Guzmán, Ricardo Henriques, Guillaume Jacquemet, Johanna Ivaska
Published in Nano Letters, March 2020 (see publication)
| Artificial intelligence for microscopy: what you should know |
Lucas von Chamier, Romain F Laine, Ricardo Henriques
Published in Biochemical Society Transactions, August 2019 (see publication)
| Automating multimodal microscopy with NanoJ-Fluidics |
Pedro Almada, Pedro M Pereira, Siân Culley, Ghislaine Caillol, Fanny Boroni-Rueda, Christina L Dix, Guillaume Charras, Buzz Baum, Romain F Laine, Christophe Leterrier, Ricardo Henriques
Published in Nature communications, March 2019 (see publication)
| NanoJ: a high-performance open-source super-resolution microscopy toolbox |
Romain F Laine, Kalina L Tosheva, Nils Gustafsson, Robert DM Gray, Pedro Almada, David Albrecht, Gabriel T Risa, Fredrik Hurtig, Ann-Christin Lindås, Buzz Baum, Jason Mercer, Christophe Leterrier, Pedro M Pereira, Siân Culley, Ricardo Henriques
Published in Journal of Physics D: Applied Physics, February 2019 (see publication)