Yue (Julie) Yuan


Understanding the dynamics and mechanisms of HIV-1 cell entry
Started on September, 2017
Supervision: Prof. Ricardo Henriques, Prof. Mark Marsh, Prof. Dylan Owen, Dr. Romain Laine
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Host receptor engagements is one of the first steps during HIV entry. There is still a lack of explicit knowledge on the precise stoichiometry of the virus Env-receptor interaction or of how flexible this might be for a successful fusion event, especially from the perspective of predominant viral target cells (CD4+ T cells). A better understanding of PM receptor distributions, and how this is modulated by the virus, is still required. I am aiming at characterising this dynamic process using Super-Resolution Microscopy on a single-cell level. We have successfully validated a pipeline to quantitatively analyse the topology of membrane receptors, CD4 and CCR5. Our next step is to investigate further what receptor topology makes a fusion-efficient by monitoring viral entry in living CD4+ T cells.

Research themes with our lab

Collaborators

Joe Grove

Grove Lab, University College London, UK

Mark Marsh

Cellular Mechanisms of Virus Entry and Assembly Lab, University College London, UK

Publications with our group